Thyroid hormone action in the hypothalamus in LPS-induced NTIS. Male THAI mice were treated with 150 μg/animal LPS i.p.; Luciferase expression represents local TH-action. (A, B) YA (2–3 months old), (A) ARC-ME Luciferase mRNA levels, (B) ARC-ME Dio2 mRNA levels, (C, D) AG (1 year old), (C) ARC-ME Luciferase mRNA levels, (D) ARC-ME Dio2 mRNA levels. n(YA) = 5/group; n(AG) = 8–9/group; figure shows Tukey Box Plots, α = 0.05; *p < 0.05, **p < 0.01, ***p < 0.001. ARC-ME, arcuate nucleus-median eminence; TH, thyroid hormone.