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. 2023 Jan 30;21:57. doi: 10.1186/s12967-023-03891-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Genetic characteristics and transcriptional changes of cuproptosis related genes in CM. A. Somatic mutation and CNV landscape of all patients in TCGA-SKCM data set. B. Somatic mutation and CNV landscape of 10 CRGs in all patients in TCGA-SKCM dataset. C. Network diagram of PPI analysis and enrichment analysis of 10 CRGs. D. Differential expression of 10 CRGs in TCGA and GTEx datasets between CM patients and normal skin tissues. E, F. Differential expression of 10 CRGs in GSE15605 (E) and GSE46517 (F) datasets between CM patients and normal skin tissues. *: P < 0.05; **: P < 0.01; ***: P < 0.001; ****: P < 0.0001