Table 3.

Pharmacokinetic properties of the selected molecules capsaicin, rosamarinic acid and resveratrol

Molecules	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	log Kp (cm/s)
Capsaicin	High	Yes	No	Yes	No	No	Yes	Yes	-5.62
Rosamarinic acid	Low	No	No	No	No	No	No	No	-6.82
Resveratrol	High	Yes	No	Yes	No	Yes	No	Yes	-5.47