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. 2023 Jan 26;17:237–260. doi: 10.2147/DDDT.S390883

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© 2023 Huang et al.

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A schematic representation shows the outlines on studying the potential molecular mechanisms of action of Zuogui Jiangtang Shuxin formula (ZGJTSXF). The main active compounds of ZGJTSXF were identified by UPLC-Q-Exactive-Orbitrap-MS analysis of medicated rat serum. The potential targets for ZGJTSXF in treating DCM were also identified through analysis of multiple databases. The common targets were subjected to in silicon network pharmacology (C-T network and PPI network) analysis and pathway enrichment analysis. The mouse DCM model was established to experimentally validate the predicted targets and pathways through multiple cellular and molecular approaches.