CHA2DS2‐VASc			HAS‐BLED
	0–1387 (11.5%)	2–31,712 (50.1%)	≥41,260 (37.5%)	<32,369 (74.6%)	≥3808 (25.4%)
Age [years], mean ± SD	60.0 ± 8.4	70.3 ± 8.5	77.1 ± 7.3	70.7 ± 9.9	74.4 ± 8.1
Body Weight (kg), mean ± SD	72.6 ± 11.9	67.2 ± 12.2	62.3 ± 11.8	66.1 ± 12.6	65.5 ± 11.8
CrCl [mL/min], mean ± SD	82.2 ± 23.1	66.4 ± 22.4	52.2 ± 20.6	64.2 ± 24.2	58.9 ± 22.2
CHA2DS2‐VASc score, mean ± SD	0.8 ± 0.4	2.5 ± 0.5	4.7 ± 0.9	2.9 ± 1.4	3.9 ± 1.5
Medical history, n (%)
Ischaemic stroke	0 (0.00)	94 (5.49)	413 (32.78)	207 (8.74)	281 (34.78)
Major or CRNM bleeding	5 (1.29)	42 (2.45)	59 (4.68)	46 (1.94)	56 (6.93)
Clinical events at 1 year, n (%/year) [95% CI]
Major bleeding (ISTH)	3 (0.79) [0.25; 2.45]	21 (1.27) [0.83; 1.95]	19 (1.58) [1.01; 2.48]	25 (1.09) [0.74; 1.61]	16 (2.08) [1.28; 3.40]
Fatal bleeding	0 (0.00) [0.00; NA]	2 (0.12) [0.03; 0.48]	2 (0.17) [0.04; 0.66]	2 (0.09) [0.02; 0.35]	2 (0.26) [0.06; 1.03]
Major GI bleeding	1 (0.26) [0.04; 1.86]	5 (0.30) [0.13; 0.72]	12 (1.00) [0.57; 1.76]	10 (0.43) [0.23; 0.81]	7 (0.91) [0.43; 1.90]
Intracranial Hemorrhage	0 (0.00) [0.00; NA]	7 (0.42) [0.20; 0.88]	5 (0.41) [0.17; 1.00]	7 (0.30) [0.15; 0.64]	4 (0.52) [0.19; 1.37]
Hemorrhagic stroke	0 (0.00) [0.00; NA]	5 (0.30) [0.13; 0.72]	4 (0.33) [0.12; 0.88]	6 (0.26) [0.12; 0.58]	3 (0.39) [0.12; 1.20]
Ischemic stroke or TIA	2 (0.53) [0.13; 2.10]	20 (1.21) [0.78; 1.87]	23 (1.92) [1.28; 2.90]	25 (1.09) [0.74; 1.61]	20 (2.61) [1.69; 4.05]
All‐cause mortality	3 (0.79) [0.25; 2.44]	25 (1.50) [1.01; 2.22]	30 (2.48) [1.74; 3.55]	37 (1.61) [1.16; 2.22]	13 (1.67) [0.97; 2.88]
Cardiovascular mortality	1 (0.26) [0.04; 1.86]	8 (0.48) [0.24; 0.96]	13 (1.08) [0.62; 1.85]	15 (0.65) [0.39; 1.08]	6 (0.77) [0.35; 1.72]
Net clinical outcome at 1 year
Ischemic or hemorrhagic stroke, SEE, MI, major bleeding (ISTH), all‐cause mortality	8 (2.11) [1.06; 4.22]	60 (3.65) [2.83; 4.70]	64 (5.40) [4.22; 6.89]	81 (3.55) [2.86; 4.42]	42 (5.54) [4.10; 7.50]