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. 2023 Jan 13;12:1078272. doi: 10.3389/fonc.2022.1078272

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Copyright © 2023 Sun, Zhang, Xiao, Li, Chen, Li and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The histopathological and immunohistochemical features of Case 1 diagnosed as TLC. (A) The histopathological features of the surgical resection specimen of Case 1. The scale bar of the pathological overview picture is 1,500 μm, and the scale bars of the enlarged field of view are 200 and 100 μm, respectively. The pathological features in the solid and dashed boxes have been further zoomed in and displayed. The red dashed circle indicates the focal necrotic area visible within the tumor. The black dashed box shows mitosis (red arrows) and a large number of polygonal, transparent tumor cells (black arrows). The yellow dashed box shows a typical histopathology of trichilemmal keratinization (green arrows) and cellular atypia. The blue dashed line indicates the peripheral palisading of clear cells. The blue solid box shows the tumor invasion. (B) The staining features of Case 1. Case 1 showed positivity for PAS staining. As for immunohistochemical staining, Case 1 showed positivity for Ki-67 (60%+), Pan CK, EMA, p53, and p63 but negativity for CEA and S-100. The scale bar is 200 μm.