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. 2023 Jan 13;12:1078272. doi: 10.3389/fonc.2022.1078272

Figure 2.

Figure 2

Radiology and histopathological features of Case 2 diagnosed as TLC. (A, B) MRI images of Case 2, taken respectively at her 57 (A) and 58 (B) years old, showing TLC nodules in the occipital region inside the red dotted circle. (C) The Emission Computed Tomography image of Case 2 showed that the bones of the whole body were not invaded by any tumor. (D) The histopathological features of Case 2. The scale bar of the pathological overview picture is 2,000 μm, and the scale bar of the enlarged field of view is 100 μm. The pathological features in the solid boxes have been further zoomed in and displayed. The lesion had many polygonal transparent tumor cells (indicated by black arrows), trichilemmal keratinization (indicated by green arrows), and calcification (indicated by blue arrows). (E) The staining features of Case 2. Case 2 showed positivity for PAS staining. As for immunohistochemical staining, Case 2 showed positivity for Ki-67 (35%), p53, and p63 but negativity for p40, HMB45, S-100, and EMA. The scale bar is 100 μm.