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. 2023 Jan 13;12:1078272. doi: 10.3389/fonc.2022.1078272

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Copyright © 2023 Sun, Zhang, Xiao, Li, Chen, Li and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The histopathological and immunohistochemical features of Case 3 diagnosed as TLC. (A, B) Macroscopic and dermoscopic view of the TLC lesion of Case 3. (C) The histopathological features of Case 3. The scale bar of the pathological overview picture is 1,000 μm, and the scale bar of the enlarged field of view is 100 μm. The pathological features in the solid and dashed boxes have been further zoomed in and displayed. The lesion had many polygonal transparent tumor cells (indicated by black arrows) and pathological mitosis (indicated by red arrows). The blue dashed line indicates the peripheral palisading of cells. (D) The staining features of Case 3. Case 3 showed positivity for PAS staining. As for immunohistochemical staining, Case 3 showed positivity for Ki-67 (80%+), Pan CK, CK5/6, p53, p63, and EMA but negativity for CK7, CK20, CEA, HMB45, S-100, and CgA. CD34 was diffusely expressed. The scale bar is 100 μm.