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. 2023 Jan 17;12:e81032. doi: 10.7554/eLife.81032

Figure 2. Successive MRI of several patients carrying different TRPM3 variants.

*Normal MRI: the fissures of the vermis and cerebellar hemispheres are nearly virtual. (a–i) MRI of the patients showing variable widening of the cerebellar fissures (arrows) reflecting cerebellar (vermis and/or hemispheres) atrophy. (a–d) Patient 1, MRI at 3 years 8 months showing slight atrophy of the vermis (a-sagittal T1) and cerebellar hemispheres (B-coronal T1); and majoration of the atrophy at 10 years (c-sagittal T1 and d-coronal T2), (e–f) Patient 3; MRI at 8 years 6 months: severe atrophy of the vermis (arrow) and brainstem (star), and atrophy of the cerebellar hemispheres (sagittal and coronal T1). (g–j) successive MRIs in patient showing progressive atrophy (g: 2 years 2 months; h: 6 months; i–j: 4 years 2 months). (k and l) Patient 4; MRI at 1 years 4 months: small vermis, thin brainstem (star) and atrophy of the cerebellar hemispheres (sagittal and coronal T1).

Figure 2.

Figure 2—figure supplement 1. MRI of patient 7 and patient 8.

Figure 2—figure supplement 1.

(a–b) Patient 7, very mild and localized atrophy of the cerebellar hemispheres (arrows), stable (2 years 10 months (a); 12 years 1 month (b)). (c) Patient 8, normal posterior fossa at age of 3 years; non-specific bilateral symmetric periventricular white matter hyperintensities on FLAIR axial MRI (arrows).