Table 3.

Multivariable liner regression models assessing the relationship between reproductive hormones with white matter volume and WMH volume by sex.

	white matter volume
	Women (n=44)				Men(n=35)
Hormone	B	95% Confidence Intervals		P_value	B	95% Confidence Intervals		P_value
E ²	−4.72	−18.56	9.11	0.50	6.18	−21.80	34.16	0.67
FSH	−23.58	−43.76	−3.39	0.022^a	−0.61	−15.83	14.60	0.94
T	14.33	−2.39	31.05	0.093^b	8.06	−9.32	25.45	0.36
DHEA-S	13.89	2.50	25.27	0.017^a	−7.24	−19.48	4.99	0.25
	WMH Volume
	Women (n=44)				Men(n=35)
E ²	−0.21	−0.68	0.26	0.38	0.02	−0.97	1.01	0.97
FSH	−0.27	−1.00	0.47	0.47	0.38	−0.16	0.92	0.16
T	0.08	−0.51	0.66	0.80	0.08	−0.47	0.62	0.78
DHEA-S	−0.15	−0.52	0.22	0.42	0.28	−0.14	0.71	0.19

p-value = <0.05

p-value = <0.10

WMH = white matter hyperintensity; E²= estradiol; FSH = follicle stimulating hormone; T = testosterone; DHEA-S = dehydroepiandrosterone sulphate; WMH and sex hormone values were log 2 base transformed.