Table 1:
Birth Infant Baseline Characteristics, Nutritional Data and Growth Outcomes of Pancreatic Insufficient (PI) to Pancreatic Sufficient (PS).
| PI (N=14) | PS (N=16) | p Value | Adjusted p Value* | |
|---|---|---|---|---|
| Gestational Age (Weeks)1 | 26.8 ± 1.6 | 28.6 ± 2.3 | 0.02 | |
| Weight (g)1 | 903.6 ± 176.0 | 1052.8 ± 168.8 | 0.03 | |
| Length (cm)2 | 33.9 (33.2, 36.3) | 36.5 (35.3, 37.8) | 0.02 | |
| Head Circumference (cm)1 | 23.2 ± 1.4 | 24.9 ± 1.7 | 0.007 | |
| Male3 | 12 (86) | 5 (31) | 0.004 | |
| Small for Gestational Age3 | 1 (7) | 2 (13) | 1.0 | |
| Race3 | 0.4 | |||
| White | 6 (43) | 7 (44) | ||
| Black | 6 (43) | 9 (56) | ||
| Asian | 2 (14) | 0 (0) | ||
| Apgar at 1 Minute2 | 4 (3, 8) | 6 (4, 8) | 0.4 | |
| Apgar at 5 Minutes2 | 7.5 (6, 8) | 8 (7, 9) | 0.5 | |
| SNAP-II Scores2 | 9 (0, 25) | 2.5 (0, 22) | 0.7 | |
| Caesarean Section Delivery3 | 11 (79) | 13 (81) | 1.0 | |
| Single Birth3 | 11 (79) | 12 (75) | 1.0 | |
| Prenatal Steroids3 | 10 (71) | 14 (88) | 0.4 | |
| Surfactant3 | 6 (43) | 5 (31) | 0.7 | |
| Gestational Age at Discharge (weeks)2 | 40.1 (37.7, 44.1) | 38.9 (37.5, 41.2) | 0.6 | |
| DOL First Feeding2 | 1 (0, 1) | 1 (0.5, 1) | 1.0 | 0.8 |
| Days to Full Feedings2 | 16 (12, 17) | 10 (9.5, 11) | 0.005 | 0.4 |
| Days to Regain Birth Weight1 | 4.5 ± 4.0 | 5.9 ± 3.7 | 0.3 | 0.4 |
| Total Parenteral Nutrition (Days)2 | 15.5 (11, 18) | 9 (8, 11) | 0.03 | 0.4 |
| Length of Stay (Days)1 | 103.6 ± 28.0 | 96.0 ± 42.0 | 0.6 | 0.8 |
| MOM of Base Human Milk >70%, n (%)3,5 | 6 (43) | 13 (82) | 0.06 | 0.2 |
| Enteral Volume (ml/kg/day)2,5 | 151.6 (147.9, 161.5) | 139.5 (106.9, 163.0) | 0.3 | 0.4 |
| Enteral Energy (kcal/kg/day)2,5 | 151.1 (138.3, 163.0) | 133.6 (103.1, 157.7) | 0.2 | 0.5 |
| Enteral Protein (kcal/kg/day)2,5 | 16.1 (14.3, 17.2) | 15.8 (7.3, 18.0) | 0.7 | 0.6 |
| Enteral Fat (kcal/kg/day)2,5 | 85.4 (74.1, 93.5) | 74.9 (51.2, 87.3) | 0.2 | 0.6 |
| Enteral Carbohydrate Intake (kcal/kg/day)2,5 | 49.7 (49.0, 52.9) | 46.2 (36.3, 53.1) | 0.2 | 0.4 |
| Weight (kg)1,5 | 1.2 ± 0.3 | 1.5 ± 0.3 | 0.02 | 0.2 |
| Length (cm)1,5 | 37.0 ± 2.8 | 39.6 ± 2.7 | 0.02 | 0.4 |
| HC (cm)1,5 | 25.5 ± 2.3 | 27.3 ± 2.6 | 0.05 | 0.7 |
| Weight Velocity (g/kg/day)2,6 | 11.7 (10.4, 12.5) | 12.4 (10.7, 13.8) | 0.3 | 1.0 |
| Length Velocity (cm/week) 1,6 | 0.9 ± 0.2 | 0.9 ± 0.3 | 0.8 | 0.6 |
| HC Velocity (cm/week)2,6 | 0.8 (0.7, 0.8) | 0.8 (0.6, 0.8) | 1.0 | 1.0 |
| Change in Weight Z Score from Birth to 36 weeks PMA2 | −1.6 (−1.9, −1.2) | −1.3 (−1.8, −0.8) | 0.3 | 0.7 |
| Change in Length Z Score from Birth to 36 weeks PMA1 | −1.2 ± 0.9 | −1.00 ± 1.0 | 0.5 | 0.9 |
| Change in HC Z Score from Birth to 36 weeks PMA2 | −1.0 (−2.0, −0.6) | −1.0 (−1.5, −0.4) | 0.6 | 0.8 |
1
Mean ± SD, T-Test P-value;
2
Median (IQR), Wilcoxon Rank Sum Test P-value;
3
Frequency (%), Fisher’s Exact Test P-value;
4
Calculated using Fenton 201321;
5
At 28 Days of Life (DOL);
6
At 36 Weeks Post Menstrual Age (PMA).
DOL, Day of Life. HC, Head Circumference. PI, Pancreatic Insufficient. PS, Pancreatic Sufficient.
*
Model adjusted for gestational age, SGA, and male sex.