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. 2023 Jan 13;324(3):H293–H304. doi: 10.1152/ajpheart.00279.2022

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Published by the American Physiological Society.

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Figure 9. — Effect of chronic A61603 treatment on the response to rapid pacing. A: maximum capture rate (MCR) measured before and after chronic (2 wk) treatment with vehicle or A61603 (means ± SE, n = 7/group, P values for paired t tests). B: MCR after treatment relative to before treatment (P value for unpaired t test). C: relationship between engineered heart tissue (EHT) force (normalized) and stimulation frequency before treatment with vehicle or A61603 (n = 14) and after vehicle treatment (n = 5) (means ± SE, ****P < 0.0001, **P < 0.01, paired t tests). D: force-frequency relation after A61603 treatment (n = 6) (means ± SE, ns, not significant, paired t test).