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. 2023 Jan 13;324(3):H293–H304. doi: 10.1152/ajpheart.00279.2022

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Published by the American Physiological Society.

PMC Copyright notice

Figure 10. — Effects on chronic A61603 treatment on adrenergic receptors and contraction-related gene expression. A: expression of adrenergic receptors in engineered heart tissue (EHT) treated with A61603 (n = 6) or vehicle (n = 7). ****P < 0.0001. B: heat maps for selected contraction-related genes; values scaled from 0.4× (deep blue) to 1.6× (deep red) the average for the vehicle group. C: significantly changed biological pathways associated with prioritized genes in EHT treated with A61603 (n = 6) vs. vehicle (n = 7). Boldface indicates pathways with known links to α₁-AR signaling. Origin value on the abscissa corresponds to P = 0.05.