. 2023 Jan 31;28:100600. doi: 10.1016/j.bbih.2023.100600

Table 2.

The total number (cells/μL) of monocytes, lymphocytes, CD3⁺ T-cells, CD4⁺ T-cells, CD8⁺ T-cells, ‘double-negative’ (DN) T-cells, NK-cells, B-Cells, and subsets (naïve; CM: central memory; EM: effector memory; EMRA: EM CD45RA+) of T-cells found in peripheral blood before (Rest), during (60% and 80%), and 1 h after (1h Post) each exercise trial for the infected and non-infected participants. Data are mean ± SD. Main effects of time (Rest, 60%, 80%, 1h post), status (non-infected versus infected) and time × status interactions are shown. Statistical differences, within each status, from Rest, 60%, and 1h Post exercise trials are indicated by *, #, and $ respectively, p < 0.05.

	Rest	60%	80%	1h Post	Time F (p-value)	Status F (p-value)	Interaction F (p-value)
Monocytes
Non-Infected	315.8 ± 100.9	462.4 ± 161.4 *$	570.2 ± 181.2 *#$	332.5 ± 134.4	46.95 (<0.001)	0.396 (0.539)	1.076 (0.369)
Infected	320.5 ± 84.9	414.5 ± 80.4 *$	501.3 ± 112.4 *#$	308.3 ± 53.2	46.95 (<0.001)	0.396 (0.539)	1.076 (0.369)
Lymphocytes
Non-Infected	1584.6 ± 411.9	2253.2 ± 679.8 *$	2995.1 ± 787.8 *#$	1423.9 ± 634.1	*80.68 (<0.001)*	0.156 (0.699)	0.834 (0.483)
Infected	1899.5 ± 549.2	2328.1 ± 508.4 *$	3004.9 ± 821.4 *#$	1464.9 ± 394.3 *	*80.68 (<0.001)*	0.156 (0.699)	0.834 (0.483)
CD3+T-cells
Non-Infected	1134.4 ± 333.9	1478.6 ± 472.8 *$	1814.6 ± 488.0 *#$	1060.6 ± 492.0	38.70 (<0.001)	0.131 (0.723)	0.747 (0.530)
Infected	1339.8 ± 403.8	1549.7 ± 431.6 $	1829.6 ± 621.6 *$	1065.2 ± 252.3	38.70 (<0.001)	0.131 (0.723)	0.747 (0.530)
CD4+T-cells
Non-Infected	599.4 ± 246.9	714.9 ± 311.7	812.0 ± 352.5 *$	616.9 ± 344.2	21.36 (<0.001)	2.054 (0.174)	2.360 (0.085)
Infected	826.8 ± 212.4	919.4 ± 212.5 $	1040.7 ± 253.4 *$	675.7 ± 127.8 *	21.36 (<0.001)	2.054 (0.174)	2.360 (0.085)
Naïve CD4+T-cells
Non-Infected	225.8 ± 130.5	252.5 ± 157.6	287.6 ± 191.1	195.0 ± 139.3	21.56 (<0.001)	0.915 (0.355)	1.527 (0.221)
Infected	311.3 ± 129.3	315.6 ± 107.6	354.5 ± 81.2	220.5 ± 65.6	21.56 (<0.001)	0.915 (0.355)	1.527 (0.221)
CM CD4+T-cells
Non-Infected	143.0 ± 78.3	173.4 ± 93.8 $	192.9 ± 120.4 *$	147.3 ± 111.6	15.00 (<0.001)	0.139 (0.715)	1.195 (0.323)
Infected	172.9 ± 70.0	196.0 ± 75.6 $	207.4 ± 84.4 *$	144.9 ± 65.9 *	15.00 (<0.001)	0.139 (0.715)	1.195 (0.323)
EM CD4+T-cells
Non-Infected	186.4 ± 116.7	237.9 ± 144.7	277.7 ± 166.4 *$	218.1 ± 142.7	15.57 (<0.001)	0.585 (0.457)	1.888 (0.146)
Infected	245.3 ± 67.2	283.5 ± 86.0 $	342.0 ± 95.6 *$	214.0 ± 37.4	15.57 (<0.001)	0.585 (0.457)	1.888 (0.146)
EMRA CD4+T-cells
Non-Infected	46.8 ± 50.5	54.2 ± 51.9	70.1 ± 68.9 *	60.7 ± 62.9	3.984 (0.014)	1.980 (0.181)	1.532 (0.220)
Infected	102.8 ± 97.1	119.5 ± 109.1 $	159.9 ± 147.5 *$	96.2 ± 111.1	3.984 (0.014)	1.980 (0.181)	1.532 (0.220)
PD-1+CD4+T-cells
Non-Infected	116.7 ± 134.9	135.1 ± 161.3 $	140.2 ± 160.4 $	64.3 ± 67.6 *	7.280 (<0.001)	0.466 (0.506)	1.568 (0.213)
Infected	77.0 ± 52.0	85.9 ± 52.5	95.7 ± 54.1	63.6 ± 42.2	7.280 (<0.001)	0.466 (0.506)	1.568 (0.213)
CD8+T-cells
Non-Infected	407.7 ± 153.0	576.1 ± 272.1 *$	720.9 ± 333.5 *$	353.7 ± 142.9	26.08 (<0.001)	0.152 (0.703)	0.712 (0.551)
Infected	424.7 ± 173.1	516.9 ± 197.4 $	626.8 ± 292.6 *$	333.8 ± 127.7	26.08 (<0.001)	0.152 (0.703)	0.712 (0.551)
Naïve CD8+T-cells
Non-Infected	103.7 ± 34.9	123.7 ± 51.4	151.2 ± 68.2 *$	98.6 ± 53.8	12.37 (<0.001)	0.093 (0.765)	1.114 (0.354)
Infected	109.2 ± 79.0	112.0 ± 70.3	128.9 ± 59.7 $	91.4 ± 63.6	12.37 (<0.001)	0.093 (0.765)	1.114 (0.354)
CM CD8+T-cells
Non-Infected	34.8 ± 20.9	45.9 ± 24.8	53.5 ± 28.2 *$	34.5 ± 21.1	18.83 (<0.001)	1.562 (0.232)	0.465 (0.708)
Infected	60.0 ± 39.1	68.2 ± 48.1 $	75.3 ± 47.1 *$	52.4 ± 43.0	18.83 (<0.001)	1.562 (0.232)	0.465 (0.708)
EM CD8+T-cells
Non-Infected	167.8 ± 109.9	242.8 ± 175.8 $	304.2 ± 212.5 *$	139.9 ± 90.2	26.38 (<0.001)	0.021 (0.888)	0.229 (0.876)
Infected	176.5 ± 82.8	229.9 ± 105.5 $	281.9 ± 133.2 *$	131.4 ± 65.9	26.38 (<0.001)	0.021 (0.888)	0.229 (0.876)
EMRA CD8+T-cells
Non-Infected	102.5 ± 85.2	165.3 ± 149.0	220.2 ± 192.4 *$	82.6 ± 76.9	11.87 (<0.001)	0.545 (0.473)	0.641 (0.593)
Infected	81.8 ± 94.1	104.2 ± 109.7	154.2 ± 174.5 *$	58.6 ± 76.1	11.87 (<0.001)	0.545 (0.473)	0.641 (0.593)
PD-1+CD8+T-cells
Non-Infected	24.1 ± 32.7	36.1 ± 54.9	45.5 ± 69.0 *$	19.4 ± 30.1	5.670 (0.002)	0.765 (0.397)	0.794 (0.504)
Infected	15.3 ± 12.4	15.4 ± 10.4	25.0 ± 21.9	10.0 ± 6.0	5.670 (0.002)	0.765 (0.397)	0.794 (0.504)
DN T-cells
Non-Infected	119.5 ± 82.8	173.1 ± 122.3	264.2 ± 251.3 *$	82.9 ± 50.6 *	10.04 (<0.001)	2.82 (0.115)	1.41 (0.255)
Infected	71.8 ± 33.8	92.9 ± 39.9	129.5 ± 77.9 *$	42.7 ± 15.2 *	10.04 (<0.001)	2.82 (0.115)	1.41 (0.255)
Naïve DN T-cells
Non-Infected	8.2 ± 8.4	11.7 ± 14.6	13.9 ± 16.5 $	6.6 ± 4.8	5.17 (0.004)	1.40 (0.257)	0.664 (0.579)
Infected	5.0 ± 2.0	5.6 ± 2.3	7.6 ± 4.7	3.6 ± 1.1	5.17 (0.004)	1.40 (0.257)	0.664 (0.579)
CM DN T-cells
Non-Infected	43.5 ± 25.1	42.1 ± 23.6	41.6 ± 23.2	46.7 ± 22.7	2.56 (0.067)	0.817 (0.381)	0.604 (0.616)
Infected	52.1 ± 12.3	52.2 ± 14.3	50.9 ± 17.3	53.2 ± 11.6	2.56 (0.067)	0.817 (0.381)	0.604 (0.616)
EM DN T-cells
Non-Infected	46.7 ± 45.1	64.6 ± 63.2 $	84.2 ± 84.6 *$	37.5 ± 35.5	14.43 (<0.001)	0.551 (0.470)	0.396 (0.756)
Infected	37.5 ± 22.7	47.2 ± 25.1	60.7 ± 38.5 *$	23.3 ± 11.5	14.43 (<0.001)	0.551 (0.470)	0.396 (0.756)
EMRA DN T-cells
Non-Infected	40.7 ± 72.4	62.6 ± 109.9	126.9 ± 260.9	23.4 ± 32.4	2.43 (0.078)	1.16 (0.301)	0.794 (0.504)
Infected	12.5 ± 14.2	17.3 ± 22.2	35.0 ± 58.0	6.3 ± 5.8	2.43 (0.078)	1.16 (0.301)	0.794 (0.504)
PD-1+DN T-cells
Non-Infected	4.4 ± 5.1	4.7 ± 5.6	4.4 ± 5.4	3.7 ± 3.9	1.72 (0.178)	1.09 (0.313)	0.888 (0.455)
Infected	2.5 ± 1.4	2.8 ± 1.8	3.4 ± 2.1	2.8 ± 1.6	1.72 (0.178)	1.09 (0.313)	0.888 (0.455)
B-Cells
Non-Infected	123.6 ± 46.6	170.6 ± 67.1 *	218.5 ± 87.6 *#$	132.9 ± 48.0	21.61 (<0.001)	0.931 (0.351)	0.966 (0.418)
Infected	183.0 ± 121.8	223.1 ± 120.9 $	242.6 ± 123.4 *$	167.0 ± 86.1	21.61 (<0.001)	0.931 (0.351)	0.966 (0.418)
NK-Cells
Non-Infected	264.0 ± 105.7	499.3 ± 206.2 *$	802.3 ± 335.4 *#$	177.6 ± 67.5	63.13 (<0.001)	0.319 (0.581)	0.148 (0.931)
Infected	338.9 ± 116.6	509.4 ± 125.6 $	843.7 ± 301.6 *$	223.8 ± 99.7	63.13 (<0.001)	0.319 (0.581)	0.148 (0.931)
PD-1+NK-Cells
Non-Infected	2.1 ± 1.7	3.7 ± 3.4	5.0 ± 3.9	1.5 ± 1.2	8.301 (0.002)	0.258 (0.619)	0.581 (0.631)
Infected	2.8 ± 3.9	4.2 ± 6.8	7.6 ± 9.6 *$	1.9 ± 1.9	8.301 (0.002)	0.258 (0.619)	0.581 (0.631)