Extended Data Fig. 2. Control analysis for purity of single-cell RNA-Seq data.
a. UMAP embeddings of cells annotated as malignant per cancer type or organ system, colored by sample.
b. Control analysis for annotations of cells as malignant, using the method described by Kim et al.1. Briefly, inferred CNV profiles (from the scRNA-Seq data) were scored as the sum of the squared values (shown as the x-axis). The cells with the top scores are assumed to be malignant and each cell is then correlated with their averaged profile (y-axis). In tumors with CNVs these two measures are consistent. Color indicates the annotation as malignant or normal cells, per sample.