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. 2022 Dec 29;4(1):96–107. doi: 10.1038/s43018-022-00503-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Baseline neutralizing activity in group-1 (CONTROL: n = 24, PLASMA: n = 25), group-2 (CONTROL: n = 8, PLASMA: n = 6), group-3 (CONTROL: n = 14, PLASMA: n = 18) and group-4 (CONTROL: n = 9, PLASMA: n = 14) measured by a surrogate inhibition assay on day 1 (after randomization and prior to plasma treatment). Boxplots indicate the interquartile range and whisker length is limited to 1.5 times the interquartile range. Medians are indicated within the boxes. (b) Highest levels of neutralizing activity on day 3/5 in group-1 (CONTROL: n = 25, PLASMA: n = 26), group-2 (CONTROL: n = 8, PLASMA: n = 7), group-3 (CONTROL: n = 15, PLASMA: n = = 18) and group-4 (CONTROL: n = 10, PLASMA: n = 13) measured by a surrogate inhibition assay on day 1 (after randomization and prior to plasma treatment). Boxplots indicate the interquartile range and whisker length is limited to 1.5 times the interquartile range. Medians are indicated within the boxes. (c) Increase in neutralizing activity analyzed as the percent difference in neutralizing activity as measured by a surrogate inhibition assay on day 1 (after randomization and prior to plasma treatment) and compared to the highest level of day 3/5 in group-1 (CONTROL: n = 24, PLASMA: n = 25), group-2 (CONTROL: n = 8, PLASMA: n = 6), group-3 (CONTROL: n = 14, PLASMA: n = 18) and group-4 (CONTROL: n = 9, PLASMA: n = 13) measured by a surrogate inhibition assay on day 1 (after randomization and prior to plasma treatment). Boxplots indicate the interquartile range and whisker length is limited to 1.5 times the interquartile range. Medians are indicated within the boxes.