Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 30;4(1):128–147. doi: 10.1038/s43018-022-00491-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a, Cohort description of the AURORA Metastatic Project. b, Diagram of the shared or individual tumor DNA methylation, WGS/whole-exome sequencing (WES) and RNAseq data successfully performed on each of the 55 participants; DNAme, DNA methylation; prim, primary; met, metastasis. c, Global profiling of the DNA methylation landscape using the top 5,000 most variable cancer-associated hypermethylated CpGs in 97 paired and 34 unpaired primary and metastatic tumors. Samples were intentionally ordered by participant to visually inspect the within-participant conservation of DNA methylation patterns. d, Supervised hierarchical cluster analysis of 102 paired and 21 unpaired primary and metastatic RNA-sequenced tumors using the so-called 1,900 intrinsic gene list (~1710 genes found in this dataset)²¹. e, OncoPrint panel of DNA somatic mutations displaying 37 of the most frequently mutated genes in 41 primary and 93 metastatic tumors. The percentage on the right indicates the mutation frequency of each gene across samples; LumA, Luminal A; LumB, Luminal B, Claudin, Claudin-low; normal, normal-like; Del, deletion; Ins, insertion. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license (smart.servier.com).