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. 2022 Dec 30;4(1):128–147. doi: 10.1038/s43018-022-00491-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a. Heatmap depicting the differentially expressed (DE) signatures between primary (n = 26) and metastasis (n = 69) in the AURORA cohort using all samples. b. Heatmap depicting the DE signatures between paired primary (n = 5) and brain metastasis (n = 5) in the AURORA cohort. c. Heatmap depicting the DE signatures between paired primary (n = 6) and liver metastasis (n = 6) in the AURORA cohort. d. Heatmap depicting the DE signatures between basal-like paired primary (n = 5) and brain metastasis (n = 8) in the AURORA-RAP-GEICAM cohort. d. Heatmap depicting the DE signatures between luminals (LumA, LumB, and HER2E) paired primary (n = 21) and liver metastasis (n = 24) in the AURORA-RAP-GEICAM cohort. Significance of the differences between primary and metastasis was calculated using linear mixed models (q < 0.05 in AURORA and q < 0.02 in AURORA-RAP-GEICAM). Significant signatures are row ordered from high to low according to β coefficients (or regression coefficients) and divided according to upregulated (positive) or downregulated (negative) in metastasis. Patients are column ordered according to PAM50 molecular subtype and divided according to primary and metastasis. Signatures scores were calculated in the Level 4 RNAseq data (see Methods). Normal-like tumors and post-treatment primaries were removed from the analysis. For more information about the background/origin of the signatures listed in this figure, see Supplementary Table 3, sheet 2. LumA, Luminal A; LumB, Luminal B; LN, lymph node.