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. 2022 Dec 30;4(1):128–147. doi: 10.1038/s43018-022-00491-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a-d. Correlation heatmap representing the correlation matrix of (a) RNAseq data, n = 63 tumor pairs (gene expression values) (b) DNA methylation data, n = 65 tumor pairs (ꞵ-values), (c) DNA somatic variants, n = 20 tumor pairs (binary data: 1, mutated and 0, non-mutated) and (d) DNA copy number variants, n = 87 tumor pairs (gene-specific denoised log2 copy-ratios) of paired primary and metastatic tumors. The relationship between variables has been calculated using the Pearson correlation coefficient. e-h. Comparison of Pearson correlation means between primary and paired metastasis, random primary and metastatic tumors, primaries and metastasis belonging to different patients, primary samples belonging to different patients, and metastasis samples belonging to different patients of (e) RNAseq data, n = 63 tumor pairs (gene expression values) (f) DNA methylation data, n = 65 tumor pairs (ꞵ-values), (g) DNA somatic variants, n = 20 tumor pairs (binary data: 1, mutated, 0 non-mutated) and (h) DNA copy number variants, n = 87 tumor pairs (gene-specific denoised log2 copy-ratios). P values between groups were calculated using t-test, two-sided (panels, e, f, g, and h). In panels e, f, g, and h, all Box-and-whisker plots display the median value on each bar, showing the lower and upper quartile range of the data (Q1 to Q3) and data outliers. The whiskers represent the lines from the minimum value to Q1 and Q3 to the maximum value. P, Primary; M, metastasis.