Extended Data Fig. 8. Comparison of vaccine-induced neutralization responses, anti-spike IgG antibody avidities and T-cell responses.
a, IgG-type anti-spike antibody avidities were compared to serum neutralization activities against different SARS-CoV-2 variants in healthy individuals and hematologic patients 2-8 weeks after vaccination #2 (visit #2), 4-5 months after vaccination #2 (visit #3), and 2-8 weeks after vaccination #3 (visit #4). b, 2-9 weeks after vaccination #2 (visit #2) anti-SARS-CoV-2 spike antibody levels, antibody avidity and serum neutralization activity against different SARS-CoV-2 variants were compared with specific T-cell responses against peptides derived from SARS-CoV-2 and OC43 spike as well as adenovirus 5 hexon protein in hematologic patients. Spearman’s correlation analysis in (a, b) was performed using an asymptotic two-sided test of the null hypothesis r = 0 vs r ≠ 0 based on the t distribution with n-2 degrees of freedom. Spearman’s correlation coefficients (r) are depicted as heatmaps for the indicated time-points. P-values are depicted for all significant correlations. Absence of p-values indicates absence of significance. n – number of pairs analyzed.