Extended Data Fig. 2. Variant-centered comparison of infection-neutralization activities against SARS-CoV-2 in healthy individuals and patients with hematologic neoplasia at different time points before and after vaccination, and longitudinal evaluation of ratios between infection-neutralization and anti-spike antibody levels.
Serum dilutions for half-maximal infection-neutralization capacities normalized to 107 viral RNA copies (neutralization IC50-values) are depicted for different SARS-CoV-2 variants as box plots with median, bounds between upper and lower quartiles, and whiskers between the 10th and 90th percentiles. a, Neutralization IC50-values pre-vaccination (visit #1) from healthy individuals (n = 12) and from patients with hematologic neoplasia (n = 53) were analyzed. b, Neutralization IC50-values 2-8 weeks post vaccination #2 (visit #2) from healthy individuals (n = 21) and patients with hematologic neoplasia (n = 56) were analyzed. c, Neutralization IC50-values 4-5 months post vaccination #2 (visit #3) from healthy individuals (n = 21) and from patients with hematologic neoplasia (n = 36) were analyzed. d, Neutralization IC50-values 2-8 weeks post vaccination #3 (visit #4) from healthy individuals (n = 19) and from patients with hematologic neoplasia (n = 42) were analyzed. e, Longitudinal evaluation of ratios between infection-neutralization IC50 values for EU1 and anti-spike S1 domain antibody titers for EU1 in vaccinated healthy individuals (visits #2, #3 and #4: n = 18/20/19, respectively) and hematologic patients (visits #2, #3 and #4: n = 34/22/21, respectively). Medians and interquartile ranges (error bars) are depicted. Differences between groups were tested for their statistical significance using the two-tailed Friedman test with Dunn’s multiple testing correction in (a-d), and the Kruskal-Wallis-test with Dunn’s multiple testing correction in (e). Brackets show statistically significant differences. Absence of brackets or p-values indicates absence of significance.