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. 2023 Jan 12;5(1):129–146. doi: 10.1038/s42255-022-00715-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, UMAP plots of 24,058 monocyte-macrophages allocated to the eight clusters from Fig. 1c. b, Heat map showing top 20 cluster marker genes (top, color-coded by cluster and condition) with exemplar genes and cluster annotations labeled. c, UMAP plots of the monocyte-macrophage compartment from WT mice at SS, 3, 7 and 21 d after CLP, annotated by cluster as in a. d, Bar plots showing cluster distribution within the monocyte-macrophage compartment from WT mice after CLP. e, Representative contour plots showing flow cytometric analysis of cardiac CD45⁺CD11b⁺F4/80⁺CD163⁺RETNLA⁺ macrophages from WT mice after CLP. f, Quantification of CD163⁺RETNLA⁺ macrophages per mg of cardiac tissue. Bars show mean ± s.e.m. Two-sided P values were determined by one-way analysis of variance (ANOVA) with Tukey’s multiple comparison test. g,h, Correlation of cardiac CD163⁺RETNLA⁺ macrophage numbers with EF and cTnI levels. Data are presented as two-tailed Spearman’s rank correlation. Dashed lines represent 95% confidence intervals. Each symbol represents one animal (SS, n = 8 mice; CLP 3 d, n = 8 mice; CLP 7 d, n = 9 mice; CLP 21 d, n = 10 mice) (f,g). Results represent four independent experiments in this figure (Extended Data Fig. 3).

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