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. 2022 Oct 29;270(2):898–908. doi: 10.1007/s00415-022-11433-z

Table 2.

Mean, median, standard deviation of PUMNS, LMNS, MRC values respectively in C9Pos and C9Neg patients

C9Pos C9Neg SD P valuea
Mean Median SD Mean Median
PUMNS 129 12.5 7.6 10.0 9.0 7.3 0.010
 Bulbar 1.9 2.0 1.3 1.4 1.0 1.2 0.005
 Upper limbs 5.4 4.5 3.7 4.2 4.0 3.8 0.027
 Lower limbs 5.7 6.0 3.6 4.5 4.0 3.6 0.023
LMNS 5.2 4.0 4.0 5.2 5.0 3.4 ns
 Upper limbs 2.0 2.0 2.0 2.5 2.0 1.9 ns
 Lower limbs 2.4 2.0 2.2 2.0 2.0 1.9 ns
MRC 49.0 52.0 10.0 49.1 52.0 10.3 ns
 Upper limbs 25.2 26.0 5.3 24.0 26.0 6.2 ns
 Lower limbs 23.8 26.0 6.5 25.2 28.0 6.3 ns

ns, not significant; C9Pos, patients carrying C9orf72 repeat expansion; C9Neg, patients without C9orf72 repeat expansion; PUMNS, Penn Upper Motor Neuron Score; LMNS, Lower Motor Neuron Score; MRC, Medical Research Council; SD, standard deviation

aComparison between C9Pos and C9Neg patients