Table 3.

Tissue volumes and lesion load as derived from SAMSEG; all volumes are in units of ml and are not adjusted for age, sex, and total intracranial volumes

	Center A	Center B	Center C	Center D
Gray matter
Patients (MS)	437 ± 57	466 ± 51	454 ± 45	451 ± 51
Controls (HCs)	476 ± 54	489 ± 51	482 ± 48	480 ± 51
p (t value)	6.4 $\times$ 10–9 (− 6.09)	5.5 $\times$ 10–4 (− 3.51)	5.3 $\times$ 10–3 (− 2.88)	0.087 (− 1.77)
White matter					$\times$
Patients	406 ± 52	370 ± 36	390 ± 43	375 ± 39
Controls	423 ± 51	382 ± 41	401 ± 39	396 ± 47
p (t value)	5.4 $\times$ 10–3 (− 2.81)	0.018 (− 2.38)	0.20 (− 1.30)	0.18 (− 1.36)
Cerebrospinal fluid
Patients	392 ± 62	408 ± 48	402 ± 52	411 ± 50
Controls	373 ± 48	392 ± 46	392 ± 44	392 ± 48
p (t value)	2.2 $\times$ 10–3 (3.10)	0.011 (− 2.55)	0.31 (1.02)	0.28 (1.10)
Lesion load	5.18 ± 7.24	4.38 ± 6.29	3.60 ± 4.89	4.71 ± 4.42