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Survival of NOS2-deficient mice following infection with 105 to 106 CFU intravenously (A) or with approximately 50 CFU aerogenically (B). The M. tuberculosis strains used for infection included Erdman (open triangle) and clinical isolates CI3 (closed circle), CI4 (open circle), and CI7 (closed triangle). No wild-type C57BL/6 mouse succumbed to infection. There were five mice per group. Similar results were obtained in a second experiment.
