Table 2.

Univariable logistic regression analysis identifies female sex and older age as predictors for hematotoxicity. Abbreviations: OR, odds ratio; CI, confidence interval; PPI, proton pump inhibitior treatment

	Pooled			Lomustine-Temozolomide			Temozolomide
	OR	95% CI	P	OR	95% CI	p	OR	95% CI	p
Female sex	2.47	1.00–6.10	0.050	3.15	0.87–11.48	0.08	2.08	0.56–7.79	0.28
Age	1.08	1.02–1.15	0.011	1.09	0.99–1.19	0.06	1.08	0.99–1.18	0.09
Creatinine > 1 mg/dl	0.21	0.02–1.64	0.14	0.35	0.04–2.99	0.35	0.00	0–0	0.99
Platelets < 270/µl	0.37	0.27–1.62	0.37	0.77	0.22–2.69	0.68	0.56	0.15–2.11	0.39
PPI	0.69	0.24–2.02	0.50	0.67	0.14–3.64	0.67	0.58	0.16–2.79	0.67
Steroid treatment at baseline	1.01	0.26–3.87	0.99	2.5	0.40–15.56	0.33	0.42	0.48–3.72	0.44
Experimental arm	0.94	0.39–2.29	0.90	–	–	–	–	–	–

OR odds ratio, CI confidence interval, PPI proton pump inhibitior treatment