Table 1.
Characteristics between the IIP and other groups
| IIP (n = 82) |
Pathological non-ILD (n = 6) |
p value* |
ILD with a known cause (n = 5) |
p value** |
|
|---|---|---|---|---|---|
| Male sex | 73 (89.0) | 4 (66.7) | 0.110 | 0 | < 0.001 |
| Smoking history, yes | 79 (96.3) | 6 (100) | 0.634 | 2 (40.0) | < 0.001 |
| Tobacco, pack-years | 50.7 ± 32.8 | 69.4 ± 34.2 | 0.183 | 13.4 ± 21.0 | 0.014 |
| KL-6 level (U/mL) | 641.4 ± 371.7 | 521.3 ± 298.3 | 0.442 | 916.2 ± 443.1 | 0.116 |
| SP-D level (ng/mL) | 150.1 ± 93.5 | 106.9 ± 64.2 | 0.271 | 129.8 ± 38.7 | 0.632 |
| Pulmonary function | |||||
| VC%pred (%) | 98.6 ± 18.6 | 108.1 ± 22.4 | 0.235 | 101.8 ± 20.3 | 0.708 |
| DLco%pred (%) | 73.8 ± 20.7 | 72.0 ± 28.8 | 0.842 | 61.9 ± 22.5 | 0.216 |
| FEV1/FVC (%) | 75.5 ± 8.4 | 60.3 ± 8.1 | < 0.001 | 78.8 ± 7.9 | 0.396 |
| HRCT pattern | < 0.001 | < 0.001 | |||
| UIP | 47 (57.3) | 0 | 1 (20.0) | ||
| Probable UIP | 18 (22.0) | 0 | 0 | ||
| Indeterminate UIP | 13 (15.9) | 6 (100) | 1 (20.0) | ||
| Alternative diagnosis | 4 (4.9) | 0 | 3 (60.0) | ||
| Surgical procedure | 0.569 | 0.707 | |||
| Pneumonectomy | 1 (1.2) | 0 | 0 | ||
| Lobectomy | 61 (74.4) | 6 (100) | 3 (60.0) | ||
| Segmentectomy | 4 (4.9) | 0 | 0 | ||
| Partial resection | 16 (19.5) | 0 | 2 (40.0) | ||
| Clinical staging | 0.684 | 0.368 | |||
| I | 41 (50.0) | 2 (33.3) | 4 (80.0) | ||
| II | 24 (29.3) | 2 (33.3) | 1 (20.0) | ||
| III | 17 (20.7) | 2 (33.3) | 0 | ||
| Pathologic staging | 0.425 | 0.516 | |||
| I | 41 (50.0) | 2 (33.3) | 4 (80.0) | ||
| II | 17 (20.7) | 3 (50.0) | 1 (20.0) | ||
| III | 22 (26.8) | 1 (16.7) | 0 | ||
| IV | 2 (2.4) | 0 | 0 | ||
| AE from any cause | 24 (29.3) | 0 | 0.120 | 1 (20.0) | 0.657 |
| Postoperative AE | 13 (15.9) | 0 | 0.291 | 0 | 0.334 |
| Adjuvant therapy | 0.906 | 0.838 | |||
| Carboplatin-based | 8 (9.8) | 1 (16.7) | 0 | ||
| Cisplatin-based | 1 (1.2) | 0 | 0 | ||
| Other | 3 (3.7) | 0 | 0 |
Data were presented as n (%) or mean ± SD. IIP: idiopathic interstitial pneumonia, ILD: interstitial lung disease.
*Significance of IIP vs non-ILD.
**Significance of IIP vs ILD with a known cause
KL-6: Krebs von Den Lungen-6, SP-D: pulmonary surfactant protein-D, VC%pred: percentage of predicted vital capacity, DLco%pred: percentage of predicted diffusing capacity of the lungs for carbon monoxide, FEV1: forced expiratory volume in 1 s, FVC: forced vital capacity, PaO2: partial pressure of oxygen, HRCT: high-resolution computed tomography, UIP: usual interstitial pneumonia, AE: acute exacerbation