Table 3.
Baseline characteristics of the participants who were included in the development (GS:SFHS) and validation (GoDARTS) of the risk model for resolved neuropathic pain
| Characteristic | GS:SFHS (n = 632) | GoDARTS (n = 268) | ||
|---|---|---|---|---|
| Observationsa | Missing data | Observationsa | Missing data | |
| Remission of neuropathic pain at follow-up, n (%) | 230 (42.6) | 15 | 56 (23.7) | 14 |
| Age (years) | 60 (52–66) | 0 | 67 (61–75) | < 1 |
| Gender (% male) | 34 | 0 | 55 | < 1 |
| Social deprivation (SIMD; %) | ||||
| 1 (Most deprived) | 16 | 11 | 21 | 25 |
| 2 | 17 | 17 | ||
| 3 | 15 | 16 | ||
| 4 | 24 | 29 | ||
| 5 (Least deprived) | 29 | 16 | ||
| Depression (PROMIS SF4a T-score) | 51.8 (41.0–58.9) | 5 | 55.7 (49.0–62.2) | 7 |
| Anxiety (PROMIS SF4a T-score) | 51.2 (40.3–59.5) | 6 | 53.7 (48.0–61.4) | 10 |
| Sleep disturbance (PROMIS SF4a T-score) | 54.3 (48.4–59.8) | 11 | 56.1 (50.5–61.7) | 16 |
| Extraversion (TIPI score) | 4 (3–5) | 4 | 4 (3–4.5) | 8 |
| Agreeableness (TIPI score) | 5.5 (4.5–6.5) | 4 | 5 (4–6) | 6 |
| Conscientiousness (TIPI score) | 6 (5–6.5) | 4 | 5 (4.5–6.5) | 7 |
| Emotional stability (TIPI score) | 4.5 (3.5–6) | 3 | 4 (3.5–5.5) | 6 |
| Open to new experiences (TIPI score) | 5 (4–5.5) | 4 | 4.5 (3.5–5.5) | 7 |
| Pain catastrophising (PCS score) | 9 (4–17) | 2 | 15.5 (9–30) | 6 |
| Traumatic events before 18 years of age (%) | 48 | 3 | 44 | 2 |
| Hospital stay before 18 years of age (%) | 10 | 5 | 11 | 7 |
| Ever smoked (%) | 49 | < 1 | 60 | 1 |
| Currently drink alcohol (%) | 84 | < 1 | 62 | < 1 |
| Physical activity (%; high) | 54 | 44 | 79 | 20 |
| Health-related quality of life (EQ-5D-5L Index) | 0.710 (0.548–0.768) | 4 | 0.567 (0.277–0.710) | 6 |
| BMI (kg/m2) | 27.66 (24.41–31.70) | 7 | 32.68 (29.5525–37.245) | 0 |
| Resting heart rate (BPM) | 70 (62–77) | 4 | 72 (64.5–81.5) | 41 |
| Hypertension (%) | 39 | 7 | 34 | 0 |
| Coronary artery disease/heart disease (%) | 5 | 8 | 29 | 0 |
| Stroke (%) | 2 | 8 | 4 | 0 |
| Glucose (mmol/L) | 4.7 (4.4–5.0) | 9 | 8 (6.8–11.375) | 46 |
| Creatinine (µmol/L) | 70 (63–81) | 8 | 75 (63–93) | 1 |
| Total cholesterol (mmol/L) | 5.2 (4.5–5.925) | 8 | 4.00 (3.475–4.62) | < 1 |
| High Density Lipoprotein (mmol/L) | 1.4 (1.2–1.7) | 8 | 1.00 (0.90–1.31) | 1 |
BMI body mass index; BPM beats per minute; EQ-5D-5L EuroQoL-five dimensions-five levels; GoDARTS Genetics of Diabetes Audit and Research In Tayside Scotland; GS:SFHS Generation Scotland: Scottish Family Health Study; PCS Pain Catastrophising Scale; PROMIS patient-reported outcomes measurement information system; SF4a short form four answers; SIMD Scottish Index of Multiple Deprivation; TIPI ten item personality inventory
aObservations reported as percentages or median and interquartile range, excluding missing data