Table 2.
List of metabolites that were significantly associated with APOE E2. FC, Est, SE, and Adj pvalue are fold change (FC) comparing E2 to E3 carriers, E2 effect relative to E3 in log-scale (Est), standard error of the effect (SE), and adjusted p values from the meta-analysis. NECS, Arivale, BLSA, LGP, and LLFS are the FC estimates obtained in the individual studies. Age effect is the effect of 1 year of age on log-transformed changes of the metabolites (adjusted by sex, education, genome-wide principal components) and values in parenthesis are the unadjusted p values to test the hypothesis of a significant age effect
| Standardized name | Super class | FC | Est (SE) | Adj pvalue | FC NECS | FC Arivale | FC BLSA | FC LGP | FC LLFS | Age Effect | Metabolite |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CE 22:6 | Sterol lipid | 0.78 | − 0.24(0.05) | 0.00004 | 0.85 | 0.75 | 0.002 (0.08) | 22:6 Cholesterol ester | |||
| DG 18:1_20:4 | Glycerolipids | 1.19 | 0.18(0.03) | 0.00004 | 1.21 | 1.24 | 1.16 | − 0.008 (0) | Oleoyl-arachidonoyl-glycerol (18:1/20:4) [1]* | ||
| CE 20:4 | Sterol lipid | 0.84 | − 0.17(0.03) | 0.00005 | 0.84 | 0.85 | − 0.004 (0) | 20:4 Cholesterol ester | |||
| DG 16:0_18:2 | Glycerolipids | 1.19 | 0.17(0.03) | 0.00007 | 1.23 | 1.18 | 1.23 | 1.17 | − 0.003 (0.026) | Palmitoyl-linoleoyl-glycerol (16:0/18:2) [1]* | |
| DG 16:0_18:1 | Glycerolipids | 1.23 | 0.21(0.04) | 0.00022 | 1.25 | 1.00 | 1.21 | 1.23 | − 0.004 (0.002) | Palmitoyl-oleoyl-glycerol (16:0/18:1) [1]* | |
| DG 18:1_18:1 | Glycerolipids | 1.16 | 0.15(0.03) | 0.00052 | 1.19 | 1.14 | 1.13 | 1.16 | − 0.001 (0.274) | Oleoyl-oleoyl-glycerol (18:1/18:1) [1]* | |
| DG 18:1_18:2 | Glycerolipids | 1.15 | 0.14(0.03) | 0.00105 | 1.21 | 1.14 | 1.16 | 1.12 | − 0.001 (0.633) | Oleoyl-linoleoyl-glycerol (18:1/18:2) [1] | |
| PE 36:1 | Glycerophospholipids | 1.13 | 0.12(0.03) | 0.00543 | 1.16 | 1.12 | − 0.006 (0) | ||||
| CE 22:5 | Sterol lipid | 0.87 | − 0.14(0.04) | 0.00615 | 0.87 | 0.87 | 0.002 (0.046) | 22:5 Cholesterol ester | |||
| DG 18:2_18:2 | Glycerolipids | 1.15 | 0.14(0.04) | 0.01417 | 1.31 | 1.14 | 1.17 | 1.12 | − 0.002 (0.194) | linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]* | |
| MG 18:1/0:0/0:0 | Glycerolipids | 1.26 | 0.23(0.07) | 0.03020 | 1.49 | 1.19 | 1-Oleoylglycerol (18:1) | ||||
| SM 18:1;O2/24:0 | Sphingolipids | 0.93 | − 0.07(0.02) | 0.03020 | 0.99 | 0.94 | 0.86 | 0.92 | − 0.01 (0) | Lignoceroyl sphingomyelin (d18:1/24:0) | |
| LPE 18:2 | Glycerophospholipids | 1.08 | 0.08(0.02) | 0.03521 | 1.04 | 1.05 | 1.19 | 1.09 | 0.001 (0.107) | 1-Linoleoyl-GPE (18:2)* | |
| PC P-16:0/20:4 or PC O-16:1/20:4 | Glycerophospholipids | 1.10 | 0.09(0.03) | 0.06860 | 1.03 | 1.14 | 1-(1-Enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)* | ||||
| LPE 18:1 | Glycerophospholipids | 1.08 | 0.07(0.02) | 0.07108 | 1.00 | 1.09 | 1.14 | 1.08 | − 0.002 (0.044) | 1-Oleoyl-GPE (18:1) | |
| 6-Hydroxyindole sulfate | Organic acids | 1.20 | 0.18(0.06) | 0.07108 | 1.18 | 1.22 | 6-Hydroxyindole sulfate | ||||
| DG 16:0_18:1 | Glycerolipids | 1.19 | 0.18(0.06) | 0.07108 | 1.25 | 1.16 | Palmitoyl-oleoyl-glycerol (16:0/18:1) [2]* | ||||
| DG 16:1_18:2 | Glycerolipids | 1.15 | 0.14(0.05) | 0.08292 | 1.66 | 1.14 | 1.11 | 1.15 | 0 (0.998) | Palmitoleoyl-linoleoyl-glycerol (16:1/18:2) [1]* | |
| DG 18:2_20:4 | Glycerolipids | 1.19 | 0.17(0.06) | 0.08238 | 1.24 | 1.16 | Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]* |