Fig. 3.

UA ameliorates deficits in associative learning and exploratory behavior in 3xTg-AD mice. A Cued fear conditioning test: percentage of time spent frozen, where Bl refers to their baseline freezing, LT refers as freezing during application of light and tone cues and Ps refers to freezing after the cues stopped. Data was quantified as mean ± SEM (n = 9–10) in 12-month-old female mice. One-way repeated measures ANOVA with pairwise post hoc Fisher LSD test. B Elevated plus maze: exploratory behavior measured as count of head dip movements while animal body was located at maze center. Here decreased head dipping in the 3xTg/CTRL mice, indicate a depression in exploratory behavior, which is reversed in the 3xTg/UA mice. Data was quantified as mean ± SEM (n = 9–10) in 12-month-old female mice. *One-way ANOVA with pairwise post hoc Fisher LSD test p value < 0.05. C Y-maze: total distance traveled as a measure of baseline exploratory behavior, which is reduced in the 3xTg-AD mice. Data was quantified as mean ± SEM (n = 9–10) 12-month-old female mice. *One-way ANOVA with pairwise post hoc Fisher LSD test p value < 0.05