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. 2022 Dec 28;45(2):1095–1113. doi: 10.1007/s11357-022-00708-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Hippocampal Aβ-containing plaques positively correlate with spatial learning and memory in 3xTg-AD mice. Analysis of the linear correlation between the extension of Aβ plaques in the hippocampus of mice (as depicted in Fig. 1A) vs. spatial learning and memory assessed in the MWM. Aβ plaques vs. escape latency- day 4 (graphs on right) or Aβ plaques vs. platform crossings- second probe test (graphs on left). Data is shown for A all 3xTg-AD subjects, regardless of diet (n = 18); B 3xTg-AD mice on control diet (n = 9), C 3xTg-AD mice on UA diet (n = 9)