Fig. 4.

Illustration of correlation between AT₄R and cytokine levels. Scatter plot showing the correlation (and 95% confidence interval of the regression line) between levels of (A) AT₄R and brain IL-6 (n = 30) (p = 0.871) in Alzheimer’s dementia group. (B) AT₄R and brain IL-6 (n = 30) (r =  − 0.523 p = 0.003) in Alzheimer’s dementia group treated with angiotensin receptor blockers. (C) AT₄R and serum IL-1β (n = 26) (p = 0.898) in Alzheimer’s dementia group. (D) AT₄R and serum IL-1β (n = 26) (r =  − 0.460 p = 0.020) in Alzheimer’s dementia group treated with angiotensin receptor blockers. Spearman’s correlation analysis was used