Table 1.
Demographic and clinical characteristics for NCs, MCI, and AD
| Demographic information | NC n = 750 | MCI n = 564 | AD n = 259 |
|---|---|---|---|
| Baseline age | 73.2 ± 6.2 | 73.2 ± 7.2 | 74.2 ± 8.01 |
| Education | 16.4 ± 2.6 | 16.0 ± 2.81 | 15.6 ± 2.71 |
| APOE ε4 + | 230 (31%) | 349 (62%)1 | 190 (73%)1,2 |
| Male sex | 339 (45%) | 332 (59%)1 | 147 (57%)1 |
| BMI | 26.9 ± 5.1 | 26.5 ± 4.9 | 25.6 ± 4.71 |
| Hypertension | 326 (43%) | 261 (46%) | 130 (50%) |
| Diabetes | 52 (7%) | 42 (7%) | 19 (7%) |
| Baseline ADAS13 | 8.9 ± 4.4 | 17.3 ± 6.71 | 30.6 ± 8.31,2 |
| Baseline TMT-B | 81.6 ± 41.2 | 121.6 ± 68.61 | 198.7 ± 85.71,2 |
| Baseline RAVLT-immediate | 45.3 ± 9.9 | 33.0 ± 9.71 | 22.4 ± 7.41,2 |
| Baseline RAVLT-learning | 6.0 ± 2.4 | 4.0 ± 2.61 | 1.8 ± 1.81,2 |
| Baseline RAVLT-Perc-forgetting | 35.6 ± 22.1 | 64.35 ± 31.11 | 88.96 ± 22.11,2 |
Values are expressed as mean ± standard deviation or number of participants (percentage %). Statistically significant results were reported if they survived Bonferroni correction. 1Statistically significant difference from NC. 2Statistically significant difference from MCI. BMI body mass index, APOE ε4 + number and percentage of people with at least one ε4 allele, NC normal control, MCI mild cognitive impairment, AD Alzheimer’s disease, ADAS13 Alzheimer’s Disease Assessment Scale–13, TMT-B Trail Making Test-B, RAVLT Ray Auditory Verbal Learning Test, Perc-forgetting percent forgetting. For baseline ADAS-13, TMT-B, and RAVLT-Perc-forgetting, higher scores represent poor performance. For RAVLT-immediate and RAVLT-learning, lower scores represent poor performance