Table 4.
Linear mixed model results showing interactions between cognition and WMH at all regions of interest for NCs, MCI, and AD
| Frontal | Temporal | Parietal | Occipital | |||||
|---|---|---|---|---|---|---|---|---|
| T stat | p | T stat | p | T stat | p | T stat | p | |
| ADAS13 | ||||||||
| WMH | 4.58 | < .001* | 1.74 | .08 | 4.68 | < .001* | 3.64 | < .001* |
| MCI:WMH | 12.18 | < .001* | 10.45 | < .001* | 11.84 | < .001* | 12.10 | < .001* |
| AD:WMH | 0.86 | 0.39 | 1.53 | 0.12 | 2.18 | 0.03* | 1.64 | 0.10 |
| TMT-B | ||||||||
| WMH | 5.10 | < .001* | 3.27 | .001* | 5.46 | < .001* | 4.53 | < .001* |
| MCI:WMH | 5.96 | < .001* | 6.23 | < .001* | 6.41 | < .001* | 6.51 | < .001* |
| AD:WMH | − 1.26 | .20 | 0.36 | .71 | 0.51 | .60 | 1.00 | .31 |
| RAVLT-immediate | ||||||||
| WMH | − 5.78 | < .001* | − 3.36 | < .001* | − 5.98 | < .001* | − 3.90 | < .001* |
| MCI:WMH | − 3.74 | < .001* | − 3.42 | < .001* | − 3.78 | < .001* | − 4.07 | < .001* |
| AD:WMH | 2.04 | .04 | − 0.61 | .54 | 1.05 | .29 | 0.25 | .79 |
| RAVLT-learning | ||||||||
| WMH | − 4.52 | < .001* | − 3.61 | < .001* | − 5.81 | < .001* | − 4.49 | < .001* |
| MCI:WMH | 0.77 | .43 | 0.85 | .39 | 1.62 | .10 | 0.91 | .36 |
| AD:WMH | 2.93 | .003* | 2.82 | .005* | 3.35 | < .001* | 3.53 | < .001* |
| RAVLT-Perc-forgetting | ||||||||
| WMH | 5.00 | < .001* | 3.26 | 0.001* | 5.04 | < .001* | 4.40 | < .001* |
| MCI:WMH | − 0.23 | 0.81 | − 0.72 | 0.47 | − 1.12 | 0.26 | − 0.57 | 0.56 |
| AD:WMH | − 2.21 | 0.03* | − 1.75 | 0.08 | − 1.87 | 0.07 | − 1.99 | 0.05 |
*Results that are significant when uncorrected and bolded values represent those that remained significant after correction for multiple comparisons. WMH white matter hyperintensity, MCI mild cognitive impairment, AD Alzheimer’s disease, ADAS13 Alzheimer’s Disease Assessment Scale-13, RAVLT Ray’s Auditory Verbal Learning test, TMT-B Trail Making Test-B, Perc-forgetting percent forgetting