Table 2a.
Summary of results of bupropion on sexual desire outcome.
| Study |
NHMRC
Evidence Hierarchy |
Quality | Scale |
Improvement in Sexual
Desire/Interest |
|---|---|---|---|---|
| Safarinejad 2011 [20] | Level II | 100% | FSFI, CGI-SF | ↑*** |
| Safarinejad 2010 [21] | Level II | 100% | BISFW, GEQ | ↑*** |
| Segraves 2004 [17] | Level II | 100% | CSFQ | ↔ |
| Thase 2006 [22] | Level II | 100% | CSFQ | ↑* |
| Clayton 2004 [23] | Level II | 94% | CSFQ | ↔ |
| Kennedy 2006 [24] | Level II | 94% | Sex FX | ↔ |
| Hartmann 2012 [25] | Level III-3 | 100% | FSFI | ↔ |
| DeFronzoDobkin 2006 [26] | Level III-3 | 93% | CSFQ | ↑** |
| Segraves 2001 [27] | Level III-3 | 87% | CGI-I, investigator rated scale | ↑*** |
| Mathias 2006 [28] | Level III-3 | 64% | ASEX | ↑* |
| Gitlin 2002 [29] | Level IV | 79% | ASEX | ↑** |
Legend: * p<0.05; ** p<0.01; *** p<0.001; ↑ improve; ↔ no difference statistically. NHMRC = Australian National Health and Medical Research Council. FSFI = Female Sexual Function Index; CSFQ = Changes in Sexual Functioning Questionnaire, Sex FX = Sex Effect Scale, ASEX = Arizona Sexual Experiences Scale, CGI-SF = Clinical Global Impression-Sexual Function and BISFW = Brief Index of Sexual Functioning for Women].