Table 5.

Summary of studies reported on effectiveness of bupropion in subjects with HSDD.

Study	NHMRC Evidence Hierarchy	Quality	Scale	Improvement in Sexual Functioning as a Whole	Improvement in Sexual Desire/Interest
Safarinejad 2010 [21]	Level II	100%	BISFW, GEQ	↑***	↑***
Segraves 2004 [17]	Level II	100%	CSFQ	↑***	↔
Hartmann 2012 [25]	Level III-3	100%	FSFI	↔	↔
Segraves 2001 [27]	Level III-3	87%	CGI-I, investigator rated scale	↑***	↑***

*** p<0.001; ↑ improve; ↔ no difference statistically. NHMRC = Australian National Health and Medical Research Council. FSFI = Female Sexual Function Index; CSFQ = Changes in Sexual Functioning Questionnaire, CGI-I = Clinical Global Impression-Investigator Rated, BISFW = Brief Index of Sexual Functioning for Women and GEQ = Global Effiacy Question