TABLE 1.
Clinicopathological characteristics of YTHDF1 expression on ESCC tissue sections.
| YTHDF1 low expression | YTHDF1 high expression | P | ||
|---|---|---|---|---|
| 64 (%) | 56 (%) | |||
| Gender | Male | 47 (55.3) | 38 (44.7) | .319 |
| Female | 17 (48.6) | 18 (51.4) | ||
| Age | <55 | 12 (48.0) | 13 (52.0) | .353 |
| ≥55 | 52 (54.7) | 43 (45.3) | ||
| Tumor location | Upper thoracic | 4 (57.1) | 3 (42.9) | .574 |
| Middle thoracic | 48 (55.8) | 38 (44.2) | ||
| Lower Thoracic | 12 (44.4) | 15 (55.6) | ||
| T stage | T1 | 4 (66.7) | 2 (33.3) | .004* |
| T2 | 20 (83.3) | 4 (16.7) | ||
| T3 | 40 (45.5) | 48 (54.5) | ||
| T4 | 0 (.0) | 2 (100.0) | ||
| N stage | N0 | 38 (64.4) | 21 (35.6) | .054 |
| N1 | 17 (48.6) | 18 (51.4) | ||
| N2 | 6 (30.0) | 14 (70.0) | ||
| N3 | 3 (50.0) | 3 (50.0) | ||
| TNM stage | I | 5 (71.4) | 2 (28.6) | .006* |
| II | 37 (68.5) | 17 (31.5) | ||
| III | 20 (36.4) | 35 (63.6) | ||
| IV | 2 (50.0) | 2 (50.0) | ||
| Differentiation | High | 9 (69.2) | 4 (30.8) | .114 |
| Moderate | 52 (54.2) | 44 (45.8) | ||
| Low | 3 (27.3) | 8 (72.7) | ||
ESCC, esophageal squamous cell carcinoma; YTHDF1: YTH N6-methyladenosine RNA-binding protein 1; * Meaningful p-value.