TABLE 3.
Univariate and multivariate Cox regression analyses of clinical factors associated with 5-year overall survival on ESCC tissue sections.
| Univariate cox regression analysis | Multivariate cox regression analysis | Multivariate cox regression analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Gender | .823 | .358, 1.892 | .646 | ||||||
| Age | 1.890 | .665, 5.371 | .232 | ||||||
| Tumor location | 1.247 | .745, 1.683 | .445 | ||||||
| T stage | 1.933 | 1.136, 3.288 | .015* | 1.799 | 1.048, 3.085 | .033* | 1.813 | 1.063, 3.091 | .029* |
| N stage | 1.722 | 1.219, 2.434 | .002* | 1.605 | 1.125, 2.290 | .009* | 1.693 | 1.189, 2.413 | .004* |
| TNM stage | 1.716 | 1.290, 2.281 | <.001* | 1.615 | 1.088, 2.398 | .017* | 1.589 | 1.093, 2.310 | .015* |
| Differentiation | 1.459 | .710, 2.997 | .303 | ||||||
| YTHDF1 expression | 1.630 | 1.158, 2.296 | .019* | 1.549 | 1.098, 2.186 | .013* | |||
| HNRNPC expression | 1.921 | 1.453, 5.872 | .003* | 1.563 | 1.311, 5.349 | .007 | |||
95% CI, 95% Confidence Interval; ESCC, esophageal squamous cell carcinoma; HR: hazard ratio; YTHDF1: YTH N6-methyladenosine RNA-binding protein 1; HNRNPC: heterogeneous nuclear ribonucleoprotein C; * Meaningful p-value.