Table 4.

Descriptive statistical analysis of models.

Responses	p-values of factors							Fit statistics
	Model	A	B	C	AB	AC	BC	Adjusted regression coefficient ($R_a^2$)	Predicted regression coefficient ($R_p^2$)	Regression coefficient ($R^2$)	Coefficient of variance (% CV)	Adequate precision
Zeta potential (mV)	0.0058*	0.0063*	0.0081*	0.0022*	0.0141*	0.0379*	0.0850	0.9999	0.9994	1.0000	0.1075	355.5386
Vesicle size (nm)	< 0.0001*	0.0001*	0.0011*	< 0.0001*	–	–	–	0.9938	0.9859	0.9965	1.29	52.1541
Entrapment efficiency of Dox (%)	0.0093*	0.0159*	0.0036*	0.0077*	0.0680	0.0656	0.0149*	0.9998	0.9984	0.9999	0.246	224.6999
Entrapment efficiency of ICG (%)	0.0080*	0.0063*	0.0033*	0.0077*	0.0231*	0.1112	0.1010	0.9988	0.9988	1.0000	0.101	284.601
Invitro drug release at 72nd hour (%)	0.0201*	0.0260*	0.0082*	0.0193*	0.0807	0.0327*	0.0270*	0.9992	0.9927	0.9999	0.9219	102.2501
Hyperthermia temperature (ºC)	0.0297*	0.0552	0.0117*	0.0353*	0.0353*	0.1392	0.0438*	0.9982	0.9839	0.9997	0.2696	71.8132

*Significant p value (< 0.05), model term p value (< 0.10).