Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 30;6:120. doi: 10.1038/s42003-023-04463-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Unsupervised hierarchical clustering using global levels of DNA methylation levels distinguish injured/regenerated (IR) (N = 12 retinas) (black) from injured/non-regenerated (INR) (N = 12 retinas) RGCs (red). b A circos plot depicts the genome-wide relative location of regeneration-associated hyper DMRs (N = 151; red; middle circle) and hypo DMRs (N = 186; blue; inner circle) on each chromosome (outer circle) across the genome. c Unsupervised hierarchical clustering using the DNA methylation data from only the CpGs located in the 337 DMRs comparing IR against INR RGCs. Corresponding heatmap shows the level of methylation at each CpG from each RGC group. Low levels of DNA methylation (red) and high levels of DNA methylation (purple) are depicted. d A pie chart shows the proportion of DMR locations relative to standard genic structures. e, f Weblogos display the motif of a representative transcription factor significantly enriched in hypermethylated (DLX5) and hypomethylated (ELF5) regions.