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. 2023 Jan 30;14(1):70. doi: 10.1038/s41419-023-05607-4

Fig. 5. The effect of SCDEs on the regulation of M1/M2 polarization in vivo.

Fig. 5

A Representative images of PKH26 (red)-labeled SCDEs absorbed by macrophages/microglia in vivo. Scale bars: 20 µm. The right images were high-resolution versions of the boxed regions in the left images. Scale bars: 2 µm. B Representative immunofluorescence staining images of iNOS (green) and ED1 (red). Nuclei were labeled with DAPI (blue) in each group (n = 3). Scale bar: 20 μm. D Quantitative analysis of the ED1+ cells and iNOS+ cells (n = 3). F Representative western blots showing the reduction of iNOS in vivo (n = 3). C Representative immunofluorescence staining images of CD206 (green) and ED1 (red). Nuclei were labeled with DAPI (blue) in each group (n = 3). Scale bar: 20 μm. E Quantitative analysis of the ED1-positive cells and CD206-positive cells (n = 3). G Representative western blots showing the increase of CD206 in vivo (n = 3). Data were presented as mean ± SEM. Results were analyzed by One-way ANOVA. Significance: *P < 0.05, **P < 0.01, ***P < 0.001.