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. 2023 Jan 4;20(2):158–174. doi: 10.1038/s41423-022-00963-1

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Fig. 3 — TRIM27 deficiency causes enhanced intestinal inflammation and gut dysbiosis over time. a, b qPCR analysis of Tnf mRNA expression in the SI (a) and LI (b) from 2–16-week-old Trim27^+/+ and Trim27^-/- mice. c, d qPCR analysis of Il1b mRNA expression in the SI (c) and LI (d) from 2–16-week-old Trim27^+/+ and Trim27^-/- mice. e Taxonomic cladogram generated via linear discriminant analysis effect size (LEfSe) analysis showing the bacterial taxa (phylum, class, order and family) in 8-week-old (left) and 16-week-old (right) Trim27^+/+ and Trim27^-/- mice. Green and red indicate an increased abundance in Trim27^+/+ and Trim27^-/- mice, respectively. In a–d, statistical analyses were performed using two-way ANOVA with Sidak’s multiple comparisons test. The data are shown as box-and-whisker plots displaying the medians, interquartile ranges (boxes) and minima and maxima (whiskers) (a–d, n = 5). P > 0.05, not significant (ns); **P < 0.01; ***P < 0.001; ****P < 0.0001