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. 2023 Jan 30;14:477. doi: 10.1038/s41467-023-36079-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Microbially produced B12 was shown to be responsible for the lipid-lowing effect of silymarin in both rats and germ-free mice. Additional liver transcriptome analyses demonstrated that the improvement in liver lipid metabolism was explained by reduced lipogensis and enhanced fatty acid oxidation. Moreover, the delta changes of serum B12 associated negatively with the fluctuations of serum triglycerides in humans.