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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Hepatology. 2023 Feb 17;77(3):774–788. doi: 10.1002/hep.32692

FIGURE 5.

FIGURE 5

HCC EV ECG score for detecting early-stage HCC in the CSMC independent validation cohort. (A) Heatmaps summarize relative duplex real-time immuno-PCR signals of plasma samples from patients with early-stage HCC (BCLC Stage 0-A, n = 35) and patients with liver cirrhosis (n = 37). Significantly higher immuno-PCR signals of (B) EpCAM+ CD63+ HCC EVs, CD147+ CD63+ HCC EVs, and GPC3+ CD63+ HCC EVs were observed in patients with HCC compared to those with cirrhosis. (C) ROC curve of HCC EV ECG score for detecting early-stage HCC from cirrhosis in the CSMC independent validation cohort. ASGPR1, Asialoglycoprotein receptor 1; AUROC, area under the receiver operating characteristic curve; BCLC, Barcelona Clinic Liver Cancer; CSMC, Cedars-Sinai Medical Center; EpCAM, epithelial cellular adhesion molecule; EV, extracellular vesicle; GPC3, Glypican 3 Protein; HCC, hepatocellular carcinoma; PCR, polymerase chain reaction; ROC, receiver operating characteristic.