Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Stress and hypoxia mediated increase of the tryptophan derived metabolic kynurenine 128 pathway in detriment of 5-HT generation. Indoleamine 2,3-dioxygenase (IDO), being upregulated 129 by stress, enhances toxic kynurenine signaling. By reducing tryptophan hidroxylase (TPH) activities, 130 hypoxia concomitantly diminishes 5-HT availability.
