Table 1.
Details of studies included in Mendelian randomization analyses.
| Consortium | Phenotype | First author | Sample size | Year | Note |
|---|---|---|---|---|---|
| MRC-IEU | Diabetic retinopathy | NA | 14,584 | 2021 | https://gwas.mrcieu.ac.uk/datasets/finn-b-DM_RETINOPATHY_EXMORE/ |
| Background diabetic retinopathy | 2,026 | https://gwas.mrcieu.ac.uk/datasets/finn-b-DM_BCKGRND_RETINA/ | |||
| Proliferative diabetic retinopathy | 8,681 | https://gwas.mrcieu.ac.uk/datasets/finn-b-DM_RETINA_PROLIF/ | |||
| GSCAN | Cigarettes per day | Liu M (11) | 337,334 | 2019 | https://www.nature.com/articles/s41588-018-0307-5 |
| Age Of Smoking Initiation | 341,427 | ||||
| Alcoholic drinks per week | 335,394 | ||||
| MRC-IEU | Ever smoked | Ben Elsworth | 461,066 | 2018 | https://gwas.mrcieu.ac.uk/datasets/ukb-b-20261/ |
| Alcohol intake frequency | 462,346 | https://gwas.mrcieu.ac.uk/datasets/ukb-b-5779/ | |||
| Neale Lab | Body mass index | Neale | 336,107 | 2017 | http://www.nealelab.is/blog/2017/9/11/details-and-considerations-of-the-uk-biobank-gwas |
| GIANT | Waist-to-hip ratio | Shungin D (10) | 210,082 | 2015 | https://www.nature.com/articles/nature14132 |
| Hip circumference | 211,114 | ||||
| Waist circumference | 231,353 |
MRC-IEU, MRC Integrative Epidemiology Unit; GSCAN, GWAS & Sequencing Consortium of Alcohol and Nicotine use; GIANT, Genetic Investigation of ANthropometric Traits.