Table 3.
Sensitivity test of Mendelian randomization analyze of the associations between unhealthy lifestyle and risk of DR.
| Exposure | MR-Egger regression analysis | Cochran’s Q test | IVW method (multiplicative random-effects) |
|||
|---|---|---|---|---|---|---|
| Intercept | P-value | Q statistic | P-value | OR (95% CI) | P-value | |
| Smoke | ||||||
| Age Of Smoking Initiation | 0.023 | 0.432 | 9.79 | 0.081 | 1.19(0.55,2.55) | 0.659 |
| Cigarettes per day | 0.001 | 0.888 | 30.92 | 0.056 | 1.16(1.03,1.31) | 0.013* |
| Ever smoked | 0.008 | 0.335 | 92.89 | 0.079 | 0.77(0.46,1.28) | 0.318 |
| Alcohol intake | ||||||
| Alcohol intake frequency | 0.010 | 0.112 | 147.44 | <0.001* | 1.09(0.92,1.30) | 0.304 |
| Alcoholic drinks per week | 0.001 | 0.927 | 34.24 | 0.315 | 0.96(0.69,1.34) | 0.814 |
| Obesity | ||||||
| Body mass index | -0.003 | 0.251 | 348.61 | 0.005* | 1.42 (1.29,1.56) | <0.001* |
| Waist circumference | -0.001 | 0.886 | 66.64 | 0.289 | 0.92(0.79,1.06) | 0.246 |
| Hip circumference | -0.003 | 0.622 | 72.67 | 0.390 | 0.85(0.76,0.95) | 0.005* |
| Waist-to-hip ratio | 0.004 | 0.776 | 52.13 | 0.024* | 1.15(0.93,1.41) | 0.197 |
IVW, inverse‐variance weighted; MR, Mendelian randomization.