Table 8.
Male fertility studies.
| Authors (reference) | Type of study | Study design | Aim | Results | Conclusion |
|---|---|---|---|---|---|
| Mohanty et al. (269) |
in vivo human male |
Bioinformatic analysis of available databases | Assessment of the effect of HSPA2 polymorphism on male fertility | The existence of a variant of the HSPA2 gene negatively affecting fertility was demonstrated | HSPA2 polymorphism may cause male infertility |
| Choobineh et al. (270) |
in vivo human male |
Clinical experiment | Assessment of the effect of testosterone administration on the reduction of the negative impact on the testes after spinal cord injury | Increased semen quality in the study group was demonstrated | Early administration of testosterone after a spinal cord injury may positively influence fertility preservation |
| Snyder et al. (271) |
in vivo animal male |
Animal medical experiment (mouse) | Analysis of the effect of ADAD1 and ADAD2 expression on male fertility | Mice with blocked expression of ADAD1 and ADAD2 were completely sterile | ADAD1 and ADAD2 are key genes related to fertility |
| Chi et al. (272) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of Kindlin-2 expression on male fertility | Testicular hypoplasia and male infertility have been observed after Kindlin-2 expression was blocked | Kindlin-2 is a key gene related to fertility |
| Wei et al. (273) |
in vivo animal male |
Animal medical experiment (mouse) | Establishing the mechanism of reducing fertility in males with the Wip1 phosphatase mutation | Changes in the expression of numerous proteins related to cell adherence, apoptosis, response to the stimulation of pro-inflammatory cytokines and spermatogenesis were detected | Disabling Wip1 alters the expression of numerous fertility-related genes |
| Xiang et al. (274) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of Crybb2 expression on male fertility | After blocking Crybb2, fertility decreased significantly | Crybb2 is one of the key fertility genes |
| Sun et al. (275) |
in vivo animal male |
Animal medical experiment (mouse) | Searching for genes important for male reproduction using the CRISP method | A significant role of 13 genes in spermatogenesis and sperm maturation was determined | Genetic mutations can directly lead to infertility |
| Xia et al. (276) |
in vivo animal male |
Animal medical experiment (mouse) | Analysis of the effect of testis-expressed protein 33 (TEX33) expression on male fertility | Mice with blocked TEX33 expression showed no impairment of fertility | TEX33 is not related to fertility |
| Shah et al. (277) |
in vivo animal male |
Animal medical experiment (mouse) | Analysis of the influence of c4orf46 expression on male fertility | Mice with blocked c4orf46 expression showed no impairment of fertility | C4orf46 is not related to fertility |
| Holcomb et al. (278) |
in vivo animal male |
Animal medical experiment (mouse) | Analysis of the effect of expression of testis-specific serine proteases PRSS44, PRSS46, and PRSS54 on male fertility | Mice with blocked expression of testis-specific serine proteases PRSS44, PRSS46, and PRSS54 showed no impairment of fertility | Testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are probably not related to fertility |
| He et al. (279) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of Trim69 expression on male fertility | No changes in fertility were observed after Trim69 blockade | Trim69 is not a key gene associated with fertility |
| Xiuying et al. (280) |
in vivo animal male |
Animal medical experiment (Rana nigromaculata) | Assessment of the effect of microcystin-leucine-arginine on reproduction | Decrease in fsh synthesis after mclr administration | Exposure to mclrs negatively affects fertility |
| Yang et al. (281) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of T-2 toxin on male fertility | The administration of T-2 toxin caused a significant decrease in the concentration of hormones of the hypothalamic-pituitary-testis axis, which reduced fertility | Exposure to T-2 toxin negatively affects fertility |
| Zhang et al. (282) |
in vivo animal male |
Animal medical experiment (rat) | Assessment of the effect of exposure to Mn3O4 nanoparticles on male fertility | The administration of Mn3O4 nanoparticles caused damage to the testes and decreased fertility | Exposure to Mn3O4 nanoparticles negatively affects fertility |
| Domínguez-Salazar et al. (283) |
in vivo animal male |
Animal medical experiment (rat) | Analysis of the effect of sleep deprivation on the blood-testicular barrier in males | In rats subjected to sleep deprivation, a decrease in the expression of proteins that build the blood-testicular barrier was observed, which leads to reduced fertility; fertility functions return to normal after sleep deprivation is reversed | Sleep deprivation has a negative effect on fertility, however it is reversible |
| Ye et al. (284) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of metformin administration in obese males on fertility | Increased fertility in the study group was demonstrated | Metformin can be used to treat male fertility |
| Akomolafe et al. (285) |
in vivo animal male |
Animal medical experiment (mouse) | Assessment of the effect of star apple fruit on male fertility | Increased fertility in the study group was demonstrated | Star apple fruit can be used as a nutritional supplement to improve fertility |
| Silva et al. (286) |
in vitro human male |
Bioinformatics analysis of gene relationships (in men) | Searching for links between amyloid precursor protein (APP) and genes related to fertility | Numerous relationships of APP expression have been determined not only with genes related to spermatogenesis and sperm maturation, but also with genes regulating the interaction of sperm with oocytes | APP expression may be related to fertility |
| Miyata et al. (287) |
in vivo animal male |
Bioinformatic analysis of available databases | Analysis of potential genes related to male fertility | 54 genes potentially unrelated to male fertility were identified | The pool of genes suspected of being associated with male fertility was limited |
| Lu et al. (288) |
in vivo animal male |
Bioinformatic analysis of available databases | Analysis of potential genes related to male fertility | 30 genes potentially unrelated to male fertility were identified | The pool of genes suspected of being associated with male fertility was limited |