Table 9.
The relationship of testosterone and female fertility.
| Authors (reference) | Type of study | Study design | Aim | Results | Conclusion |
|---|---|---|---|---|---|
| Sjaarda et al. (303) |
in vivo human female |
Clinical experiment | Assessment of the effect of testosterone and anti-müllerian hormone levels on conception and pregnancy | In the group of women with a high concentration of testosterone or amh, non-ovulatory cycles are statistically significantly more frequent; the influence of changes in the concentration of these hormones does not affect the course of pregnancy | High levels of testosterone or amh can negatively affect fertility |
| Lathi et al. (304) |
in vivo human female |
Clinical experiment | Assessment of the effect of testosterone levels on pregnancy in women with PCOS | No statistically significant differences in the course of pregnancy were shown | Testosterone in patients with PCOS does not adversely affect pregnant patients |
| Valdimarsdottir (305) |
in vivo human female |
Clinical experiment | Assessment of the effect of testosterone levels in the second trimester on pregnancy in women with PCOS and the relationship between testosterone levels and body weight | The higher the body weight, the higher the testosterone concentration; high testosterone levels during the second trimester positively correlate with the risk of preeclampsia | High testosterone levels in pregnant women may result in a higher risk of preeclampsia |
| Chinnathambi et al. (306) |
in vivo animal female |
Animal medical experiment (rat) | Assessment of the effect of testosterone on the condition of the uterine arteries during pregnancy in a female | A significant increase in the expression of pro-inflammatory factors and changes in the expression of factors determining the tension in the artery wall were demonstrated | Testosterone can negatively affect the vascularization of the uterus in pregnancy |
| Sun et al. (307) |
in vivo human female |
Clinical experiment | Assessment of the influence of testosterone concentration on the effectiveness of ovarian stimulation and the course of pregnancy achieved by IVF | Low testosterone levels correlate with a poor response to ovarian stimulation, no association with the course of pregnancy has been demonstrated | The use of testosterone during ovarian stimulation may increase the effectiveness of these treatments |
| Chen et al. (308) |
in vivo human female |
Clinical experiment | Assessment of the influence of testosterone concentration in women on the effectiveness of the ovarian stimulation | Optimal testosterone concentrations have been demonstrated at various stages of the ovarian stimulation | The use of testosterone during the ovarian stimulation process may increase the effectiveness of these treatments |
| Saharkhiz et al. (309) |
in vivo human female |
Clinical experiment | Assessment of the influence of testosterone administration on ovarian response in IVF cycles | An improvement in ovarian response in women in the study group and a higher pregnancy rate was demonstrated | Testosterone administration in women with a poor ovarian response to stimulation may be effective in IVF |