Table 2.
Clinical Outcomes of PWID With BJI Between All-IV and Partial-Oral Treatment Groups
| All IV (n = 12) | Partial Oral (n = 74) | |
|---|---|---|
| Days of definitive IV antibiotics,a mean (SD) | 35.1 (12.5) | 16.0 (15.3) |
| Days of definitive oral antibiotics, mean (SD) | 0 | 45.4 (22.3) |
| Days of total definitive antibiotics, mean (SD) | 35.1 (12.5) | 60.7 (22.9) |
| Days of hospital stay, mean (SD) | 35.4 (49.9) | 17.0 (13.) |
| Disposition after hospital dischargeb | ||
| Housed,c No. (%) | 4 (40) | 34 (46) |
| Medical respite, No. (%) | 2 (20) | 20 (27) |
| Postacute facilities, No. (%) | 1 (10) | 11 (15) |
| Hospitalized entire duration of antibiotic treatment, No. (%) | 2 (20) | 0 |
| Mobile home, No. (%) | 0 | 2 (3) |
| Tent, shelter, or street, No. (%) | 1 (10) | 2 (3) |
| Unknown, No. (%) | 0 | 5 (7) |
| Patient-directed discharge, No. (%) | 1 (9) | 11 (14) |
| Follow-up with infectious diseases or surgery, No. (%) | 7 (78) | 49 (66) |
| 90-d failure rate, No. (%) | 6 (50) | 13 (20) |
| 90-d failure rate by sensitivity analysis,d No. (%) | 6 (50) | 21 (28) |
| 180-d failure rate, No. (%) | 7 (58) | 14 (21) |
| 180-d failure rate by sensitivity analysis,d No. (%) | 7 (58) | 22 (30) |
Primary outcome was dichotomized. Failure included death before definitive treatment plan and treatment failure, and cure included confirmed and presumed cure.
Abbreviations: BJI, bone and joint infection; IV, intravenous; MSSA, methicillin-susceptible Staphylococcus aureus; NA, not applicable; PWID, people who inject drugs.
Duration of dalbavancin: 7 days were counted toward IV antibiotics if the patient only received 1 dose of it; 42 days if the patient received 2 doses.
In the all-IV group, the percentage was calculated for those who survived to be discharged. Two deaths occurred in the all-IV group. One patient with concurrent spinal osteomyelitis and MSSA aortic valve endocarditis died after the valvular surgery, and the other died of respiratory failure from high cervical osteomyelitis–associated myelopathy.
Patient’s own home or home of friends or family, support housing, or motel.
Sensitivity analyses for failure rates assumed all patients who were lost to follow-up or transferred care failed treatment.